Author(s): Trisha Sarkar

Abstract:
Arthritis is one of the most common diseases affecting the elderly population, more than 100 types of arthritis are found with different prevalence and medical symptoms. Out of which osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common ones however no such medical treatment is available to cure the disease. Diet therapy had always played a crucial role in many diseases such as diabetes, cardiovascular diseases and many more. The objective of this review work is to evaluate the therapeutic potential of hesperidin, luteolin and coumaric acid that can be found from our daily diet. These phytochemical has anti-oxidative, anti-inflammatory, immunomodulatory and enzyme inhibitory effects. Scientific evidence revealed that these components exert beneficial effects on RA through several cellular mechanisms including down regulation of pro-inflammatory cytokines such as, IL-6, TNF-a and NF-jB, inhibition of cartilage degradation with destructive metal proteinases, suppression of oxidative stress and enhancement of antioxidant performance. It can be concluded that hesperidin, luteolin and coumaric acid obtained from our diet can have immense effect to alleviate the effect of rheumatoid arthritis both symptomatically and by stopping RA- induced bone destruction. It can be an effective treatment option however more research is required to understand how these dietary phytochemicals can directly affect rheumatoid arthritis.

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