Author(s): Dr. Mukilan Ramadoss, Dr. Angelie Jessica Subbiah and Dr. Manibalan Vijayaraman

Abstract:
Autonomic work of heart can be read through heart rate variability (HRV). Numerous studies are available on rodent electrocardiography. Heart is sensitive to various therapeutic agents. Small rodents like rats and mouse are used instead of large animals because of their low cost and easy handling. In recent years there has been shift in the ways of ECG monitoring in rats and has enabled researchers to receive ECG method that closely resembles human ECG monitoring. Use of anesthesia on rodent for HRV has proven to alter the autonomic activity of heart and also the implanted telemetric electrode will have its impact on rodent electrocardiography. Surface recording of ECG in a conscious rodent model will provide exact electrocardiographic assessment without the influence of external factors.

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