This study aimed to enhance leg muscle power, agility, and aerobic endurance in 13-15-year-old boys by integrating plyometric exercises with agility ladder drills. A cohort of 45 participants underwent pretest and post-test assessments, measuring vertical jump performance, agility through the T-Test, and aerobic endurance with the multistage fitness test. Data were analysed using descriptive statistics, the Wilcoxon signed-rank test, and the Mann-Whitney U test. Significantly improved power (P=0.006), agility (p=0.001), and endurance (P=0.001) were observed within the experimental group. Comparing the experimental and control groups revealed notable differences in agility (P=0.000) and endurance (p=0.000), with no significant variance in power (P=0.416). These findings highlight the positive effects of combining plyometric exercises and agility ladder drills on the physical performance of 13-15-year-old boys, recommending this approach for enhancing power, agility, and endurance.